South Dakota Medication Aide Practice Test

Itraconazole (Sporanox) is a systemic antifungal that is particularly known for its potential to cause liver toxicity. This risk is due to its metabolism in the liver, where it can lead to hepatotoxic effects, especially in individuals with predisposing factors such as existing liver dysfunction or prolonged use at high doses. Monitoring liver function tests is often recommended during treatment with itraconazole to ensure that any liver-related side effects are detected early.

The other antifungal options, while they may have their own side effects and risks, are less commonly associated with significant liver toxicity in comparison to itraconazole. For instance, fluconazole can have liver effects but is generally considered safer, particularly in terms of hepatotoxicity. Terbinafine and griseofulvin also have side effect profiles, but the severity and prevalence of liver toxicity with itraconazole distinguish it in this context.